A Compilation of Cellular and Tissue Xenotransplantation Studies (1838-2022)

The success of transplantation to treat human diseases has greatly increased the demand for organs and tissues. Xenotransplantation, the use of animals as donors, is viewed increasingly as a solution to this problem. The pig-to-NHP model has become the standard for preclinical studies of cell and tissue xenotransplantation prior to starting a clinical trial. This is A Compilation of Cell and Tissue Xenotransplantation Studies (1838-2022): A Promising Approach for the Treatment of Diseases and a collection of reminiscences by surgeons and scientists who made significant research contributions toward achieving successful transplantation of animal cells and tissues into humans. It records the works of the world's leading researchers in this field which will impact the future medical care of patients with diabetes, liver failure, neurodegenerative disorders, corneal blindness, etc. It also provides a comprehensive overview of applications of cellular and tissue xenotransplantation for a range of diseases especially those that result from tissue loss or dysfunction. The importance of the decellularization technique in animal tissues and organs as implantable biomaterials in the field of regenerative medicine and tissue engineering is also highlighted. Essential reading for physicians, scientists, and lay persons with an interest in xenotransplantation; those caring for patients with life-threatening diseases; and also those interested in understanding the potential of genetic and tissue engineering in science and medicine. This book charts a historical record of the research which has contributed to the advancement of medicine called "the next great medical revolution." Many believe we are on the threshold of clinical trials using genetically modified animals as organ donors. If successful, the benefits of clinical xenotransplantation will be enormous and will represent one of the greatest advances in modern medicine.