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Anglický jazyk
Anti-cancer effects of a-mangostin on human breast cancer cell lines
Autor: Mohamed Yousif Ibrahim Dafalla
In this book, a-mangostin (AM), a xanthone compound was investigated for its apoptosis mechanism on MCF-7 and MDA-MB-231 cell lines. The treatment of the cells with AM prompted apoptosis with cell death-transducing signals. This type of apoptosis was suggested... Viac o knihe
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O knihe
In this book, a-mangostin (AM), a xanthone compound was investigated for its apoptosis mechanism on MCF-7 and MDA-MB-231 cell lines. The treatment of the cells with AM prompted apoptosis with cell death-transducing signals. This type of apoptosis was suggested to occur through the both extrinsic and intrinsic pathways and prevention of translocation of NF-¿B from the cytoplasm to the nucleus. Our results revealed AM prompt apoptosis of the both cells through NF-¿B, Bax/Bcl-2 and HSP70 protein modulation with the contribution of caspases. Therefore, AM is deemed to have considerable potential in the control of breast cancer.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2015
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783659799150
