Concepts in Vaccine Development

Frontmatter -- Preface -- Bicentennial of the first vaccination by Edward Jenner / Kaufmann, Stefan H.E. -- Contents -- 1. The Need for New Vaccines -- 1.1. Vaccines as Evolutionary Tools: The Virulence-Antigen Strategy / Ewald, Paul W. -- 1.2. Economic Perspectives on Vaccine Needs / Ashley, Robert V. / Murray, Christopher J. L. -- 1.3. Future Immunization Strategies - Considerations from the Public Health View / Dittmann, Sieghart -- 1.4. The New Pertussis Vaccines / Klein, David L. / Heilman, Carole -- 2. General Principles of Immunology -- 2.1. Basic Principles of Immunity Against Intracellular Bacteria and Protozoa / Szalay, Gudrun / Kaufmann, Stefan H. E. -- 2.2. Viral Immunity and Vaccine Strategies / Woodland, David L. / Cole, Geoffrey A. / Doherty, Peter C. -- 2.3. Broadly Reactive HLA Restricted ¿ Cell Epitopes and Their Implications for Vaccine Design / Sidney, John / Kubo, Ralph T. / Wentworth, Peggy A. / Alexander, Jeff / Chesnut, Robert W. / Grey, Howard M. / Sette, Alessandro -- 2.4. Quantitative Considerations in the Design of Vaccination Strategies Against Pathogens Uniquely Susceptible to Cell-Mediated Attack / Bretscher, Peter -- 2.5. The Impact of the Type 1 and Type 2 ¿ Helper Cell Concept on Novel Vaccine Design with Emphasis on Protection Against Leishmania Parasites / Bogdan, Christian / Röllinghoff, Martin -- 3. General Principles of Vaccinology -- 3.1. Modern Adjuvants. Functional Aspects / Morein, Bror / Lövgren-Bengtsson, Karin / Cox, John -- 3.2. Biodegradable Microspheres as Vehicles for Antigens / Kersten, Gideon F.A. / Gander, Bruno -- 3.3. Peptide Based Vaccines / Schild, Hansjörg / Rammensee, Hans-Georg -- 3.4. Recombinant Bacteria as Vaccine Carriers of Heterologous Antigens / Hormaeche, Carlos E. / Khan, C. M. Anjam -- 3.5. Genetic Detoxification of Bacterial Toxins / Rappuoli, Rino / Pizza, Mariagrazia -- 3.6. Recombinant Virus as Vaccination Carrier of Heterologous Antigens / Perkus, Marion E. / Paoletti, Enzo -- 3.7. Naked DNA Vaccination / Shiver, John W. / Ulmer, Jeffrey B. / Donnelly, John J. / Liu, Margaret A. -- 3.8. Oral Vaccination, Mucosal Immunity and Oral Tolerance with Special Reference to Cholera Toxin / Holmgren, Jan / Czerkinsky, Cecil / Sun, Jia-Bin / Svennerholm, Ann-Mari -- 4. Specific Vaccination Strategies -- 4.1. Helicobacter pylori: Pathogenic Determinants and Strategies for Vaccine Design / Ghiara, Paolo / Covacci, Antonello / Telford, John L. / Rappuoli, Rino -- 4.2. Malaria Vaccination / Patarroyo, Manuel E. / Amador, Roberto -- 4.3. Vaccination Against Schistosomiasis: Concepts and Strategies / Riveau, Gilles J. / Capron, André -- 4.4. AIDS Vaccination / Norley, Stephen / Kurth, Reinhard -- 4.5. Vaccination Therapy Against Autoimmune Diseases / Cohen, Irun R. / Mor, Felix -- Contributors -- Index