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Anglický jazyk
Estrogen on impaired cardiac glucose uptake in cardiac hypertrophy
Autor: Vijayakumar Govindaraj
The aim of the study was to determine whether estrogen improves the impaired cardiac glucose uptake in cardiac hypertrophy which could provide a mechanism to explain the prevention of cardiac hypertrophy by estrogen using spontaneously hypertensive rats... Viac o knihe
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O knihe
The aim of the study was to determine whether estrogen improves the impaired cardiac glucose uptake in cardiac hypertrophy which could provide a mechanism to explain the prevention of cardiac hypertrophy by estrogen using spontaneously hypertensive rats (SHR). To examine this ovariectomized (OVX) and ovariectomized estradiol-implanted (OVX-E2) SHR rats were analyzed. At the end of the treatment the degree of cardiac hypertrohy, serum hormone levels, cardiac glucose uptake by FDG-PET and GLUT4 localization and expression, and cardiac hexokinase activity were analyzed. Results revealed that estrogen substitution inhibits uterine atrophy and cardiac hypertrophy in OVX+E2 group compared to OVX. PET analysis showed a significant increase in myocardial glucose uptake in OVX+E2 compared to OVX group. Confocal microscopy and western blotting demonstrated higher GLUT4 translocation on plasma membrane in E2 treated rat heart. Micro-array gene expression analysis showed differentially expressed genes that are involved in the mTOR signaling pathway which is known to be activated during cardiac hypertrophy.
- Vydavateľstvo: Scholars' Press
- Rok vydania: 2014
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783639714678
