Flavins and Flavoproteins 1987

Frontmatter -- Preface -- Organizing committee -- Acknowledgements -- Contents -- STRUCTURE AND MECHANISMS OF FLAVOENZYMES -- Absolute stereochemistry of flavins in enzyme - catalyzed reactions / Manstein, D. J. / Massey, V. / Pai, E. F. -- Conserved cysteine pairs of mercuric ion reductase: an investigation of function via site-directed mutagenesis / Walsh, Christopher T. / Moore, Melissa J. / Distefano, Mark D. -- Reduced forms of native mercuric reductase and their reactions with mercuric compounds - activity vs inhibition / Miller, S. M. / Massey, V. / Ballou, D. P. / Williams, C. H. / Moore, M. / Walsh, C. T. -- Rapid-scan stopped-flow studies of the flavoenzyme mercuric reductase during catalytic turnover / Sandström, A. / Lindskog, S. -- The penultimate cysteines in mercuric reductase aid in the reduction of mercury / Massey, V. / Miller, S. M. / Ballou, D. P. / Williams, C. H. / Moore, M. / Distefano, M. / Walsh, C. T. -- The active center of glutathione reductase at 1.54 A resolution / Karplus, P. A. / Schulz, G. E. -- Kinetic isotope effect studies on yeast, spinach and human erythrocyte glutathione reductases / Vanoni, M. A. / Wong, K. K. / Blanchard, J. S. -- Excited electronic states of flavin-containing coenzyme models / Gückel, F. / Schweitzer, D. / Becker, K. / Schirmer, R. H. / Zipplies, M. F. / Staab, H. A. -- Trypanothione reductase from Trypanosoma cruzi / Krauth-Siegel, R. L. / Schirmer, R. H. / Schöllhammer, T. -- Inactivation of two-electron reduced Escherichia coll glutathione reductase by NADPH and NADH / Arscott, L. David / Drake, Donna M. / Williams, Charles H. -- Studies on the active site of human erythrocyte glutathione reductase using 6-SCN-FAD and 6-mercapto - FAD / Massey, Vincent / Ghislat, Sandro / Ermler, Ulrich / Schulz, Georg E. -- Protein engineering of glutathione reductase from Escherichia coli / Scrutton, N. S. / Berry, A. / Perham, R. N. -- Studies on the active sites of lipoamide dehydrogenase and glutathione reductase / Sahlman, Lena / Williams, Charles H. -- Cloning, organisation and nucleotide sequence of the Azotobacter vinelandii gene for lipoamide dehydrogenase / Kok, Arie de / Westphal, Adrie H. -- Reaction of pig heart lipoamide dehydrogenase with monobromoacetone and 1,3-dibromoacetone / Lee, James S. / Williams, Charles H. -- Site-directed mutagenesis of thioredoxin reductase / Prongay, Andrew J. / Engelke, David R. / Williams, Charles H. -- Effects of urea on redox properties of streptococcal NADH peroxidase / Poole, Leslie B. / Claiborne, Al -- Three dimensional structure of baker's yeast flavocytochrome b2 / Mathews, F. S. / Xia, Z. -x. -- Mechanism of L-lactate dehydrogenation catalyzed by flavocytochrome b.2 from baker's yeast / Lederer, F. / Mathews, F. S. -- Inactivation of yeast flavocytochrone b.2 with fluoropyruvate. Modification of the active site histidine / Urban, Philippe / Florence, Lederer -- Evidence for an alteration of the flavin behavior induced by 2-methyl - 2,4 - pentandiol in cerevis iae flavocytochrome b2 / Tegoni, M. / Labeyrie, F. -- Medium chain acyl-CoA dehydrogenase from pig kidney: Aspects of the reductive half - reaction / Thorpe, C. -- Crystal structure of the general acyl-CoA dehydrogenase / Kim, J. J. P. / Wu, J. -- Inactivation of general acyl-CoA dehydrogenase from pig k i dney by the suicide substrate methylenecyclopropylacetyl - CoA. Stucture of one of the covalent flavin-inhibitor adducts / Zeller, Hans-Dieter / Ghisla, Sandro -- 2 - Bromo-octanoyl CoA: Apseudo-substrateforgeneral acyl-CoA dehydrogenase / Hall, Carole L. -- Reaction of pig kidney medium chain acyl-CoA dehydrogenase with ^ - oxidation intermediates / Powell, P. J. / Lau, S-M. / Thorpe, C. -- Medium chain acyl-CoA dehydrogenase from pig kidney: I n activation of the reduced enzyme by 2-octynoy1-CoA / Zhou, Jing-Zhi / Thorpe, Colin -- Oxidation - reduction of general acyl-CoA dehydrogenase by the butyryl-CoA / crotonyl-CoA couple. A new investigation of the rapid reaction kinetics / Schopfer, Lawrence M. / Massey, Vincent / Ghisla, Sandra / Thorpe, Colin -- Catalytic versatility of butyryl-CoA dehydrogenase from M. elsdenii / Ellison, Patricia A. / Engel, Paul C. -- Oxidation-reduction potential of glutaryl-CoA dehydrogenase from Paracoccus denitrifleans / Byron, Colleen M. / Stankovich, Marian T. / Husain, Mazhar -- 13C NMR studies on the complexes and reaction intermediates of D-amino acid oxidase / Miura, R. / Miyake, Y. -- 13C-,15N-, and 31P- NMR studies on 6-hydroxy-L-nicotine oxidase from Arthrobacter oxidans / Pust, Stefan / Vervoort, Jacques / Decker, Karl / Bacher, Adelbert / Müller, Franz -- A study on the interaction between reduced D-amino acid oxidase and ligands / Nishina, Yasuzo / Ushijiaa, Hidetaka / Tojo, Hiroaasa / Shiga, Kiyoshi -- D-Amino acid oxidase from the yeast Rhodotorula gracilis / Simonetta, M. Pilone / Casalin, P. / Pollegioni, L. / Vanoni, M. A. / Curti, B. -- Purification and properties of D-aspartate oxidase from beef kidney / Negri, Armando / Williams, Charles H. / Massey, Vincent -- Spectral and kinetic studies on Pseudomonas L-phenylalanine oxidase (deaminating and decarboxylating) / Koyama, H. / Suzuki, H. / Kawamura-Konishi, Y. -- Time - resolved flavin fluorescence of pyridoxine-5-P oxidase from sheep brain / Visser, Antonie J.W. / Kwok, Francis / Churchich, Jorge E. -- An active site thiol in lactate oxidase / Giegel, David A. / Williams, Charles H. / Massey, Vincent -- Can methylenetetrahydrofolate reductase be used to evade the methyl trap? / Green, Jacalyn M. / Ballou, David P. / Matthews, Rowena G. -- The catalytic mechanism of DNA photolyase / Jorns, Marilyn Schuman -- FLAVOENZYME STRUCTURE AND ELECTRON TRANSFER MECHANISMS -- Sequence and structure of Anacvstis nidulans flavodoxin: Comparisons with flavodoxins from other species / Laudenbach, David E. / Straus, Neil A. / Pattridge, Katherine A. / Ludwig, Martha L. -- C-13, N-15, and two-dimensional NMR techniques in flavoprotein research / Miiller, Franz / Vervoort, Jacques / Mierlo, Carlo P.M. van / Mayhew, Steve G. / Berkel, Willem J.H. van / Bacher, Adelbert -- Two dimensional NMR studies on Megasphaera elsdenii / Mierlo, Carlo van / Vervoort, Jacques / Miiller, Franz -- Flavodoxin from Anabaena 7120: Uniform N-15 enrichment and nitrogen-15 and phosphorus - 31 NMR investigations of the FMN binding site in the reduced and oxidized states / Stockman, Brian J. / Markley, John L. -- Pulse radiolysis studies on flavodoxin / Anderson, Robert F. / Massey, Vincent / Schopfer, Lawrence M. -- Resonance raman investigations of flavins and flavoproteins / Lively, Chris R. / Gustafson, William G. / McFarland, James T. -- Spectral studies on hydrogen bonded alloxazines / Koziol, J. / Szafran, M. M. / Heelis, P. F. -- Use of flavin and flavodoxin semiquinones as kinetic probes to elucidate the factors which determine reaction rate constants and biological specificity for electron transfer proteins / Tollin, Gordon / Cheddar, Glen / Hazzard, James T. / Meyer, Terrance E. / Cusanovich, Michael A. -- Factors influencing the rate of electron transfer from flavodoxin to cytochrome c. / De Francesco, Raffaele / Tollin, Gordon / Brown, Kathleen / Edmondson, Dale E. -- A computer graphics model of the complex formed between flavodoxin and the tetraheme cytochrome c.3 / Stewart, D. E. / LeGall, J. / Peck, H. D. / Wampler, J. E. / Moura, I. / Moura, J. J. G. / Xavier, A. V. / Weiner, P. K. -- Cloning and nucleotide sequence of a bacterial flavodoxin gene: Towards the site-directed mutagenesis of the flavin binding site / Krey, Grigorios D. / Vanin, Elio F. / Swenson, Richard P. -- Flavin binding site differences between Photobacterium phosphoreum lumazine protein and Megasphaera elsdenii flavodoxin. An investigation using circular dichroism and fluorescence / Visser, Antonie J. W. G. / Hoek, Arie van / Vervoort, Jacques / O'Kane, Dennis J. / Lee, John -- Ferredoxin and ferredoxin-NADP+oxidoreductase interactions: Mapping of their binding sites / Zanetti, G. / Aliverti, A. / Curti, B. / Ronchi, S. -- Complex formation between ferredoxin-NADP+-oxidoreductase and flavodoxin / Gomez-Moreno, C. / Sancho, J. / Fillat, M. / Pueyo, J. J. / Edmondson, D. E. -- Mechanism of ferredoxin-NADP+ reductase reaction NADP radical, semiquinone and fully reduced enzyme-NADP+ charge transfer complex as the reaction intermediates / Yoshikawa, Shinya / Nitta, Satoshi / Nishiyama, Kyoko / Ohnishi, Norihiro / Takeshima, Katsuhito / Ishii, Yasuhiko / Nakamura, Makoto / Matsuara, Hiroshi / Kodo, Keiun -- In vivo deactivation/activation of ferredoxin-NADP+- oxidoreductase from the cyanobacteria Anabaena variabills / Fillat, M. F. / Gómez-Moreno, C. -- Isolation from Desulfovibrio desulfuricans of a flavoprotein with NADH-H+ oxidoreductase activity towards a protein containing a rubredoxin-like center / Saint-Martin, P. / Galliano, N. / Fauque, G. / Moura, I. / Moura, J. J. G. / LeGall, J. -- Microsomal electron transport system focused on NADPH-cytochrome P-450 reductase / Nisimoto, Y. -- Time - resolved fluorescence spectroscopy on NADPH-cytochrome P-450 reductase / Bonants, Peter / Bastiaens, Phil / Visser, Ton / Miiller, Franz -- Studies on the reactions of flavin- and nicotinamide nucleotide analogues with a bacterial electron-transferring flavoprotein / O'Nuallain, Eoin M. / Mayhew, Stephen G. -- Kinetics of ligand binding, amino acid sequence, and crystallization of Chlorobium and Chromatium flavocytochrome c. / Meyer, T. E. / Holden, H. M. / Rayment, I. / Bartsch, R. G. / Cusanovich, M. A. / Van Beeumen, J. -- Redox properties of flavocytochrome c. / Cusanovich, M. A. / Bartsch, R. G. / Meyer, T. E. -- Electron transfer kinetics of phthalate oxygenase reductase, an iron sulfur center containing flavoprotein / Batie, Christopher J. / Ballou, David P. -- CD and potentiometry of the FAD of nitrate reductase / Barber, M. J. / Kay, C. J. / Solomonson, L. P. -- Kinetic studies on glutamate synthase from Azospirillum bras ilense / Ratti, S. / Vanoni, M. A. / Grandori, R. / Zanetti, G. / Curti, B. -- Redox interactions of the FAD in xanthine oxidase with other centers of the protein / Hille, Russ -- Laser flash photolysis studies of intramolecular electron transfer between the FAD and Fe/S II centers in xanthine oxidase / Edmondson, Dale E. / Hazzard, James T. / Tollin, Gordon -- Mechanism of action of chicken liver xanthine dehydrogenase / Nishino, Takeshi / Tsushima, Keizo / Schopfer, Lawrence M. / Massey, Vincent -- Interconversion between O-dependent and NAD - dependent types of rat liver xanthine dehydrogenase / Saito, T. / Nishino, T. / Tsushima, K. -- Reactivity of chicken liver xanthine dehydrogenase containing artificial flavins / Nishino, Tomoko / Nishino, Takeshi / Tsushima, Keizo / Schopfer, Lawrence M. / Massey, Vincent -- The molybdenum cofactor of milk xanthine oxidase / Fish, Kenneth M. / Massey, Vincent -- Isolation of a cDNA sequence coding for a part of xanthine dehydrogenase from rat liver / Yamazaki, K. / Nishino, T. / Tsushima, K. -- FLAVIN BIOSYNTHESIS/ METABOLISM/ AND MEDICAL ASPECTS -- Biosynthesis of flavins and deazaflavins / Bacher, Adelbert / Volka, Rainer / Keller, Paul J. / Floss, Heinz G. / Le Vana, Quang / Eisenreich, Wolfgang / Schwarzkopf, Bruno -- The icosahedral ß60 capsid of heavy riboflavin synthase (6,7- dimethyl-8-ribityllumazine synthase/riboflavin synthase) / Ladensteina, Rudolf / Hubera, Robert / Schott, Karin / Schneider, Monika / König, Astrid / Bacher, Adelbert -- Characterization of human riboflavin-binding immunoglobulins / Merrill, A. H. / Innis-Whitehouse, W. S. A. / McCormick, D. B. -- Riboflavin uptake by isolated rat kidney cells / Bowers-Komro, Delores M. / McCormick, Donald B. -- Purification and characterization of the bifunctional enzyme FAD synthetase from Brevibacterium ammoniapenes / Manstein, Dietmar J. / Pai, Emil F. -- An update on flavin metabolism in rats and humans / McCormick, D. B. / Innis, W. S. A. / Merrill, A. H. / Bowers-Komro, D. M. / Oka, M. / Chastain, J. L. -- Effects of quinacrine, tetracycline, adriamycin and chloroquine upon flavin metabolism in rats / Dutta, P. / Pinto, J. T. / Kaiczyk, G. B. / Rivlin, R. S. -- Role of flavoproteins in the neurotoxic action of MPTP / Singer, Thomas P. / Ramsay, Rona R. -- Biosynthesis of flavoproteins / Yagi, Kunio / Inagaki, Taisuke / Ichihara, Chikako / Koshizaka, Takuya / Ohishi, Nobuko / Ghisla, Sandro / Tsukagoshi, Norihiro / Udaka, Shigezo / Nishikimi, Morimitsu / Ozawa, Takayuki -- Biological and Medical Aspects of D-Amino Acid Oxidase - Biogenesis and in vivo reaction with D-propargylglycine - / Miyake, Yoshihiro / Fukui, Kiyoshi / Momoi, Kyoko / Watanabe, Fusao / Shibata, Toshihiro -- Molecular and cellular biology of D-amino acid oxidase / Fukui, Kiyoshi / Watanabe, Fusao / Shibata, Toshihiro / Momoi, Kyoko / Miyake, Yoshihiro -- Localization of D-amino acid oxidase in rat cerebellum / Horiike, Kihachiro / Tojo, Hiromasa / Aral, Ryohachi / Yamano, Toshio / Nozaki, Mitsuhiro / Maeda, Toshihiro -- Biosynthesis of D-amino acid oxidase and molecular cloning of the cDNA / Inagaki, Taisuke / Ohishi, Nobuko / Koshizaka, Takuya / Chikako, Chikako / Yagi, Kunio / Tsukagoshi, Norihiro / Udaka, Shigezo -- Characterization of a partially purified nitroaryl reductase / Bryant, Christopher / Martin, Tracy / DeLuca, Marlene -- FLAVOENZYME HYDROXYLASES -- Crystallographic studies on the mechanism of hydroxybenzoate hydroxylase from Psudomonas fluorescens / Schreuder, Herman A. / Laan, Jan M. van der / Thunnissen, Marjolein M. G. M. / Kalk, Kor H. / Swarte, Myra B. A. / Hoi, Wim G. J. / Drenth, Jan -- Applications of deuterium and tritium isotope effects to the elucidation of kinetic mechanisms of flavoprotein hydroxylases / Tu, Shiao-Chun / Wang, Lee-Ho / Yu, Yimin -- Chemical modification of tyrosine-38 in j>.-hydroxybenzoate hydroxylase from Pseudomonas fluorescens by 5'-Pfluorosulfonylbenzoyladenosine: A probe for the elucidation of the NADPH binding site? / Berkel, Willem J. H. van / Bakx, Edwin J. / Miiller, Franz / Weyer, Wicher J. / Jekel, Peter A. / Beintema, Jaap J. / Schreuder, Herman A. / Laan, Jan M. van der / Wierenga, Rik K. / Drenth, Jan / Hol, Win G. J. -- Phenol Complexes of Phenol Hydroxylase / Sejlitz, Torsten / Neujahr, Haiina Y. -- The involvement of SH-groups in cooperativity of phenol binding sites in phenol hydroxylase / Neujahr, Halina Y. -- 6-Thiocyanate-FAD and 6-mercapto-FAD as active site probes of phenol hydroxylase / Taylor, M. G. / Massey, V. -- Hysteretic behavior of anthranilate hydroxylase / Powlowski, Justin / Ballou, David / Massey, Vincent -- Redox potentials of salicylate hydroxylase / Einarsdottir, G. H. / Stankovich, M. T. / Wang, L.-H. / Tu, S.-C. -- The oxidative half-reaction of 2-methyl-3-hydroxypyridine-5 - carboxylic acid oxygenase from Pseudomonas sp. MA-1 / Brissette, Pierre / Ballou, David P. / Massey, Vincent -- Lipid stabilization of the flavin hydroperoxide in the microsomal flavin-containing monooxygenase / Poulsen, L. L. / Nagata, T. / Taylor, K. L. -- FLAVIN-DEPENDENT BIOLUMINESCENCE -- One-electron transfers in flavin systems: Relevance to the postulated C1EEL mechanism in bacterial bioluminescence / Mager, Humphrey I. X. / Tu, Shiao-Chun -- Characterization of new "bleached" products obtained on treating flavins and flavoproteins with dithionite / Mager, Humphrey I. X. -- Flavin-mediated hydrogen peroxide production by biological and chemical photosystems / De la Rosa, M . A . / Heelis, P. F. / Rao, K. K. / Hall, D. O. -- On the chemical mechanisms of bacterial luciferase, an updating / Ghisla, Sandro / Eckstein, Jens / Macheroux, Peter -- Studies on the mechanism of bacterial bioluminescence. Evidence compatible with a one electron transfer process and a CIEEL mechanism in the luciferase reaction / Macheroux, Peter / Eckstein, Jens / Ghisla, Sandro -- Structural analysis of bacterial luciferase / Baldwin, T. O. / Chen, L. H. / Chlumsky, L. J. / Devine, J. H. / Johnston, T. C. / Lin, J.-W. / Sugihara, J. / Waddle, J. J. / Ziegler, M. M. -- Sequence similarity between the a subunit of luciferase from Vibrio harvevl and clostridial flavodoxin / Murata, M. / Lee, John -- Isolation and characterization of a yellow fluorescent protein from Vibrio fischeri strain Y-1 / Daubner, Susan Colette / Astorga, Adrienne M. / Leisman, Gary / Baldwin, Thomas O. -- Purification and characterization of an unusual nonfluores cent flavoprotein from Photobacterium leiognathi / O'Kane, D. J. / Vervoort, J. / Muller, F. / Lee, J. -- Purification and some properties of FP390 from P. phosphoreum / Kasai, Sabu / Matsui, Kunio / Nakamura, Takao -- STRUCTURE, MECHANISM, AND BIOSYNTHESIS OF FLAVOENZYMES CONTAINING COVALENTLY-BOUND FLAVINS -- 8a-Imidazolylflavins: Application of their redox and spectral properties to flavoenzyme systems / Edmondson, D. E. / De Francesco, R. -- X-ray study of flavoenzymes containing covalently bound flavins / Mathews, F. S. / Lim, L. W. -- Structural studies of P-cresol methylhydroxylase / Bellamy, H. D. / Mathews, F. S. / Mclntire, W. S. / Singer, T. P. -- The chemical and stereochemical course of oxidation of 4- ethylphenol and other 4-alkylphenols by ^-cresol methylhydroxylase / Mclntire, William S. / Bohmont, Craig -- Redox properties of trimethylamine dehydrogenase / Stankovich, M. T. / Steenkamp, D. J. -- Redox properties of Escherichia coll fumarate reductase / Ackrell, Brian A. C. / Cochran, Bruce / Kearney, Edna B. / Cecchini, Gary -- Reactions of lumiflavin with aminyl and a-amino radicals of piperazine / Surdhar, P. S. / Armstrong, D. A. -- Kinetic probes of the proposed radical mechanism of monoamine oxidase / Walker, Mark C. / Edmondson, Dale E. -- Stopped-flow studies on the mechanism of the oxidation of N-methyl - 4 - phenyl - 1 , 2 , 3 , 6 - tetrahydropyridine (HPTP) by monoamine oxidase / Ramsay, Rona R. / Koerber, Steven C. / Singer, Thomas P. -- Methoxatin containing methylamine dehydrogenase: Enzyme reduction by primary amines / McWhirter, Robert B. / Klapper, Michael H. -- Interaction of bacterial sarcosine oxidase with folate derivatives / Jörns, Marilyn Schuman / Kvalnes-Krick, Kalla -- Sulfhydryl groups and the binding site of noncovalently bound FAD ofCorvnebacterlum sarcosine oxidase / Suzuki, Haruo / Kawamura-Konishi, Yasuko -- Dimethylglycine dehydrogenase from pig liver mitochondria: Purification and properties / Ichihara, Chikako / Ohishi, Nobuko / Yagi, Kunio -- Comparison of partial amino acid sequences deduced from the nucleotide sequence of a bovine adrenal monoamine oxidase cDNA clone to amino acid sequences obtained from bovine liver monoamine oxidase type B / Weyler, Walter / Powell, John / Hsu, Yun-Pung P. / Chen, Shiuan / Corey, David P. / Utterback, Margot / Titlow, Christian / Breakefield, Xandra O. -- Covalent binding of FAD to Bacillus subtllis succinate dehydrogenase / Hederstedt, L. -- 6 - Hydroxy-D-nicotine oxidase: Expression of the flavoenzyme as a covalently flavinylated polypeptide / Brandsch, Roderich -- The flavin-binding sites of 6-hydroxy-D- and 6-hydroxy-Lnicotine oxidase / Brandsch, Roderich / Hinkkanen, Ari E. / Mauch, Ludwig / Nagursky, Heiner / Decker, Karl -- LIST OF PARTICIPANTS -- AUTHOR INDEX -- SUBJECT INDEX -- Backmatter