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Anglický jazyk
Floating microspheres
Autor: Supriya Muttepawar
Gastroretentive dosage forms have potential for use as controlled-release drug delivery systems. Multiple unit systems avoid the 'all-or-none' gastric emptying nature of single unit systems. A type of multi-unit floating ziprasidone HCL Monohydrate microspheres... Viac o knihe
Na objednávku
66.60 €
bežná cena: 74.00 €
O knihe
Gastroretentive dosage forms have potential for use as controlled-release drug delivery systems. Multiple unit systems avoid the 'all-or-none' gastric emptying nature of single unit systems. A type of multi-unit floating ziprasidone HCL Monohydrate microspheres was prepared by the ionotropic gelation method with NaHCO3 as gas-forming agents being used as gas-forming agent and Eudragit L-100 and Eudragit S-100 as polymer. The solution was dropped to 1% CaCl2 solution containing 10% acetic acid for CO2 gas and gel formation. The effects of gas-forming agents on bead size and floating properties were investigated. As gas-forming agents increased, the size and floating properties increased. Bead porosity and volume average pore size, as well as the surface and cross-sectional morphology of the beads were examined with Scanning Electron Microscopy. The micromeritic properties of microspheres were found to be much improved. In-vitro drug release studies were performed and drug release kinetics were evaluated using the linear regression method.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2020
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783659327278
