Anglický jazyk

Neurotoxicity of Aluminum

Vydavateľstvo: Springer Nature Singapore
Rok vydania: 2023
Formát: Hardback
Rozmer: 241 x 160 mm
Jazyk: Anglický jazyk
ISBN: 9789819915910

Na objednávku

178.19 €

bežná cena: 197.99 €

O knihe

This book reviews the scientific literature and the authors¿ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer¿s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, its relation to neurofibrillary tangles and amyloid betäthe pathological features of AD, and the possible mechanism of aluminum inducing these pathological features. Further, the book stresses the importance of aluminum¿s complex speciation chemistry in relation to biology, and details aluminum¿s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal¿s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed, and more recently the relationship between aluminum-induced epigenetic modification on DNA and non-coding RNAs and neuron death and synaptic impairment. The second edition updates eight chapters according to the most recent researches. Content about aluminum-induced AD-like pathological features, neurotoxic effects of aluminum and aluminum alloy nanoparticles(TBD) and alumina nanoparticles induced neurotoxic and neurodevelopmental toxic effects is also added. In closing, this book provides readers with a systematic summary of aluminum neurotoxicity.