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Anglický jazyk
The immune phenotype of mice deficient for Ly49Q
Autor: Marie-Line Goulet
Plasmacytoid dendritic cells are members of the innate immune system and are particularly important in anti-viral immunity since they are the most potent producers of type I interferons. This book describes the phenotype of knockout mice for Ly49Q, a cell... Viac o knihe
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O knihe
Plasmacytoid dendritic cells are members of the innate immune system and are particularly important in anti-viral immunity since they are the most potent producers of type I interferons. This book describes the phenotype of knockout mice for Ly49Q, a cell surface receptor expressed on pDCs. In vivo, knockout mice with PGK-Neomycin insertion control early murine cytomegalovirus infection better, but no difference could be detected in mice with recombined LoxP sites. Thus, we observed a differential immune response dependent on the gene knockout strategy. In mice with PGK-Neomycin insertion, we found enhanced hematopoiesis of some populations of the myeloid lineage and lower activation of pDCs following treatment with particular Toll-like receptor ligands, which translates into diminished T cell stimulatory capacity. This suggests a role for Ly49Q in regulating hematopoiesis and pDC activation potential.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2011
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783845472300
