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Anglický jazyk
The Role of P300-Dependent MYC Acetylation in MYC Functions
Autor: Marina Vorontchikhina
I demonstrate that HAT p300 acetylates MYC preferentially at K157/158 in transfected mammalian cells. I also show that MYC overexpression increases the level of endogenous p300. Moreover, our data provides a potential link between MYC acetylation and its... Viac o knihe
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O knihe
I demonstrate that HAT p300 acetylates MYC preferentially at K157/158 in transfected mammalian cells. I also show that MYC overexpression increases the level of endogenous p300. Moreover, our data provides a potential link between MYC acetylation and its biological functions. I found that MYC acetylation at lysine 158 reduces MYC-activated apoptosis and this could be via transcriptional regulation of pro-apoptotic Nrf1 and Cytochrome c (Cyc) genes. These findings might be important for prospective drug development against MYC-dependent tumors. New therapeutics which drive transformed cells to apoptosis via prevention of MYC acetylation at K157/158 by p300 could be beneficial for the treatment of MYC-dependent cancers.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2015
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783659809163
