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Anglický jazyk
Transcriptional Regulation in White Adipose Tissue
Autor: Khwaja Islam
Peroxisome proliferator-activated receptor (PPAR) and sterol regulatory element binding protein (SREBP) families control the transcription of genes involved in lipid metabolism. I investigated the role of PPARa in regulation of lipid metabolism in white... Viac o knihe
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O knihe
Peroxisome proliferator-activated receptor (PPAR) and sterol regulatory element binding protein (SREBP) families control the transcription of genes involved in lipid metabolism. I investigated the role of PPARa in regulation of lipid metabolism in white adipose tissue (WAT) in response to various metabolic challenges, measuring the expression of lipogenic (SREBP-1c, SREBP-1a, acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS)) and cholesterogenic (SREBP-2, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR), and low density lipoprotein-receptor (LDL-R)) genes and flux through the lipogenic pathway. PPARa-deficiency was associated with reduced epididymal fat mass but increased cholesterol concentration, an effect enhanced by feeding a diet enriched in cholesterol. Adipose tissue lipogenesis was increased in PPARa-deficiency, and was further enhanced by feeding a cholesterol-rich diet. The increased lipogenesis in PPARa-deficiency was accompanied by lower mRNA expression of SREBP-1c and its target genes, ACC and FAS. Consumption of a high-cholesterol diet increased the mRNA expression of these genes in PPARa-deficiency.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2016
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783659820007
