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Anglický jazyk
Evaluation of New Bicyclic Lactone 'Michelianone'
Autor: Vichitra Kaushik
A novel bicyclic lactone 'Michelianone' (P4) has been isolated from anti-inflammatory activity guided fractionation of chloroform extract of Michelia oblonga leaf with a gradient of ethyl acetate in petroleum ether. Further P4 was screened for anti- inflammatory... Viac o knihe
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O knihe
A novel bicyclic lactone 'Michelianone' (P4) has been isolated from anti-inflammatory activity guided fractionation of chloroform extract of Michelia oblonga leaf with a gradient of ethyl acetate in petroleum ether. Further P4 was screened for anti- inflammatory activity on carrageenan and dextran induced inflammation model in rats at the dose level of 50 mg/kg body weight. Treatment of inflammed rats with P4 has showed significant reduction in inflammation caused by carrageenan (P0.01) and dextran (P0.05). Hence P4 can be considered as the principle component responsible for the anti- inflammatory activity for Michelia oblonga leaf. The characterization of P4 was done by spectral studies like IR, 1H-NMR, 13C-NMR & Mass Spectroscopy. On the basis of spectral studies the structure of P4 has been elucidated as bicyclic lactone. This is a novel bicyclic lactone isolated from the leaf of M. oblonga for the first time and given a trivial name Michelianone.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2011
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783843353090
