-
Anglický jazyk
Female sex and ER-alpha modulate cardiac ischaemic remodeling
Autor: Xiang Zhang
In this study, we present novel insights into mechanisms that account for the ERa-dependent myocardial protection against myocardial injury, with more beneficial effects in female hearts. Using a transgenic mouse model with a cardiomyocyte-specific ERa-overexpression... Viac o knihe
Na objednávku, dodanie 2-4 týždne
54.21 €
bežná cena: 61.60 €
O knihe
In this study, we present novel insights into mechanisms that account for the ERa-dependent myocardial protection against myocardial injury, with more beneficial effects in female hearts. Using a transgenic mouse model with a cardiomyocyte-specific ERa-overexpression (ERa-OE), we first demonstrated that this was associated with an increase of LVM at the basal level in both female and male mice. After MI, the cardiomyocyte-specific ERa-OE inhibited changes in LV-volumes and wall thickness only in female mice. These beneficial effects in female ERa-OE hearts were associated with increased angiogenesis and lymphangiogenesis, attenuated ventricular fibrosis and enhanced JNK phosphorylation. This study indicates that in the female sex, ERa in cardiomyocytes may have a therapeutic potential in the treatment of ischemic heart disease, leading to more efficient cardiac repair after ischemic injury.
- Vydavateľstvo: Südwestdeutscher Verlag für Hochschulschriften AG Co. KG
- Rok vydania: 2017
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783838151281
