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Anglický jazyk
Non-canonical pre-TCR signaling during T cell development
Autor: Damian Maseda Caballero
T cells undergoing maturation in the thymus need to receive a pre-TCR-delivered signal to undergo ß-selection and develop further properly. The pre-TCR is composed of a constitutively expressed pre-Ta (pTa) chain and a de novo expressed TCRß chain. A productive... Viac o knihe
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O knihe
T cells undergoing maturation in the thymus need to receive a pre-TCR-delivered signal to undergo ß-selection and develop further properly. The pre-TCR is composed of a constitutively expressed pre-Ta (pTa) chain and a de novo expressed TCRß chain. A productive recombination of the TCRß chain is mandatory to overcome the first checkpoint that controls T cells survival. However, in a very low but consistent extent, thymocytes lacking a canonical pre-TCR can differentiate further. We show that thymocytes lacking a classical pre-TCR can survive and differentiate to later developmental stages. Besides, signaling through a pTa-less TCR is enough to achieve Ca2+ influx and NF-¿B activation. In addition, we demonstrate that the mechanisms underlying cell death of thymocytes in conditions of proteasome inhibition are in great extent independent of NF-¿B activation and pre-TCR or TCR signaling, and are rather dependent on triggering the pro-apoptotic terminal UPR.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2016
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783659857614
