Progress in Tryptophan and Serotonin Research

Frontmatter -- Preface -- CONTENTS -- OPENING SESSION -- Adolf Butenandt's Work on the Metabolism of Tryptophan / Biekert, E. -- Tryptophan, the Heart of the Toxic Peptides from Amanita Mushrooms / Wieland, Th. -- Forty Years of Trypto-Fun / Witkop, Bernhard -- Indoleamine Dioxygenase - a Possible Biological Function / Hayaishi, Osamu / Yoshida, Ryotaro / Takikawa, Osamu / Yasui, Hiroaki -- QUALITATIVE AND QUANTITATIVE ANALYSIS OF TRYPTOPHAN AND ITS METABOLITES -- Liquid Chromatography/Electrochemistry Determination of Biogenic Amines: Improved Performance Using Low Dead Volume Multiple Electrode Transducers / Kissinger, P. T. -- GLC and HPLC Analysis of Tryptophan, Kynurenine and Related Metabolites / Joseph, M. H. -- Monitoring of Tryptophan Levels in Biological Fluids by HPLC: An Improved Method / Bettero, Antonio / Costa, Carlo / Allegri, Graziella -- Rapid Determination of Tryptophan and its Metabolitesalong the Kynurenine Pathway by HPLC / Costa, Carlo / Bettero, Antonio / Allegri, Graziella -- HPLC-Analysis of Xanthurenic Acid and its 8-Methyl-Ether / Schrijver, Jaap / Schaik, Frank van / Greef, Jan van der / Bos, Klaas D. / Schreurs, Wil H. P. -- Free and Total Tryptophan Microdetermination by an Automated Fluorometric Method / Bigot, Jean-Claude / Moineau, Marie-Pierre / Menez, Jean-François / Bardou, Louis-Georges -- Comparison of HPLC and GC-MS Methods for the Determination of Tryptophan and its Indole Metabolites in Biological Samples / Martínez, Emili / Adell, Albert / Suñol, Cristina / Artigas, Francesc / Tusell, Josep M. / Gelpí, Emili -- Pineal Indoles: Their Determination by High Performance Liquid Chromatography and the Influence of Diurnal Variation and Tryptophan Administration on their Level in the Rat / Young, Simon N. / Anderson, George M. -- Higher-Order Derivative Spectrophotometry for the Quantitative Determination of Tryptophan, Tyrosine and Phenylalanine in Two- and Three-Component Mixtures, Peptides and Proteins / Talsky, Gerhard / Tichy, Sibylle -- The Application of a Spectrofluorometer-Optical- Multichannel Analyzer System to the Determination of Tryptophan / Steinhart, Hans / Stützle, Petra -- Picomole Determination of Tryptophan by Derivatization to 9-Hydroxymethyl-ß-Carboline / Takai, Katsuji / Inoue, Shintaro -- Determination of Tryptophan in Food after Alkaline Hydrolysis: An Evaluation / Nielsen, Henrik K. / Hurrell, Richard F. -- Colorimetric Determination of Tryptophan in Corn-Cob Mix (CCM) / Votisky, Erika -- Comparison of Tryptophan Assays for Food Proteins / Friedman, Mendel / Levin, Carol E. / Noma, Amy T. / Montague, William C. / Zahnley, James C. -- WORKSHOP: ANALYSIS OF TRYPTOPHAN -- Discussion at the Workshop on "Analysis of Tryptophan" / Friedman, Mendel -- TRYPTOPHAN AND SEROTONIN: NEUROBIOLOGY -- Tryptophan Transport to the Brain: Newer Findings and Older Ones Reconsidered / Curzon, G. / Sarna, G. S. -- Tryptophan Availability and Serotonin Synthesis in Rat Brain: Effects of Experimental Diabetes / Fernstrom, John D. -- Anatomy and Function of Central Serotoninergic Neurons / Baumgarten, Hans Georg / Schlossberger, Hans Georg -- Serotonin Receptor Binding Sites: Localization and Role in the Brain and Peripheral Tissues / Leysen, Josée E. -- Involvement of 5-HT2 (S2)- Receptor Sites in the Serotonin-Induced Activation of Cat Platelets / De Clerck, Fred / Xhonneux, Benoit / Gommeren, Walter / Leysen, Josée -- The Regulation of 5-Hydroxytryptamine Release from Superfused Synaptosomes by Tryptophan / Suter, Hugh A. / Collard, Keith J. -- Selective Increases in High Affinity Tryptophan Transport in Synaptosomes from Different Brain Areas Incubated in Sodium-Free Media / Wilkinson, Lawrence S. / Price, Christopher J. / Collard, Keith J. -- Formation and Function of Tetrahydro-ß-Carbolines with Special Reference to their Action on [3H] - Tryptamine Binding Sites / Rommelspacher, H. / Brüning, G. -- Regulations of Serotonergic Neurons Innervating the Basal Ganglia: In vivo Release Studies / Glowinski, J. / Soubrié, P. -- Blood Platelets as Models for Neurons: Similarities of the 5-Hydroxytryptamine Systems / Pletscher, Alfred / Affolter, Hubert / Cesura, Andrea M. / Erne, Paul / Müller, Kurt -- In vivo Metabolism of 14C-5-HT, 14C-5.6-DHT and 14C-5.7-DHT by MAO/COMT/Aldehyde Dehydrogenase in Rat Brain / Baumgarten, Hans Georg / Klemm, Hans Peter / Schlossberger, Hans Georg -- Tryptophan Metabolism in the Pineal Gland / Reiter, Russel J. -- Some Physiological Responses and Effects of the Pineal Indoleamine Melatonin / Arendt, Josephine -- Pharmacologic Regulation of Serum N-Acetylserotonin / Brown, Gregory M. / Burns, Timothy G. / Psarakis, Stella / Grota, Lee J. -- N-Acetyltryptophan: Biochemical and Pharmacological Studies / Garnier, Jean-Pierre / Escande, Christine / Bousquet, Bernard / Tran, Gilles / Dreux, Claude -- Serotonin, a Major Metabolite of Tryptophan in the Rabbit Retina / Osborne, Neville N. / Patel, Saraswati / Beaton, David W. -- Effect of 5-Hydroxyanthranilic Acid on Arachidonate Metabolites Function in Platelet Aggregation System / Goda, Kiyoshi / Mori, Terutoshi / Ueda, Takashi / Kotake, Yahito -- WORKSHOP: CLINICAL AND BEHAVIOURAL EFFECTS OF TRYPTOPHAN -- Introduction to Workshop / Hartmann, E. -- Tryptophan and Human Sleep: An Analysis of 43 Studies / Hartmann, Ernest / Greenwald, Daniel -- L-Tryptophan in Chronic Insomnia / Nedopil, Norbert / Einhäupl, Karl / Rüther, Eckart / Steinberg, Reinhard -- Tryptophan (500 mg) Decreases Subjectively Perceived Sleep Latency and Increases Sleep Depth in Man / Leathwood, Peter / Pollet, Patricia -- Further Evidence of the Hypnotic Properties of Tryptophan / Lieberman, Harris R. / Corkin, Suzanne / Wurtman, Richard J. -- The Therapeutic Action of Tryptophan in Depression, Mania, and Aggression / Young, S. N. / Chouinard, G. / Annable, L. / Morand, C. / Ervin, F. R. -- The Effects of Dietary Tryptophan on Chronic Maxillofacial Pain Tolerance / Seltzer, Samuel / Pollack, Robert L. / Dewart, Dorothy / Jackson, Eric -- PATHOLOGY, CLINICAL ASPECTS -- Modulation of Serotonin Receptors by L-Valine in Hepatic Encephalopathy / Kienzl, E. / Riederer, P. / Jellinger, K. / Roth, E. / Ferenci, P. -- Effect of a B-Vitamin on Tryptophan Metabolism in South African Bantu with Pellagra / Hankes, L. V. / Jansen, C. R. / De Bruin, E. P. / Schmaeler, M. -- Studies on the Urinary Excretion of Xanthurenic Acid in Diabetics / Hattori, Masayasu / Kotake, Yazo / Kotake, Yahito / Otsuka, Hidetsugu / Shibata, Yukio -- Urinary Excretion of Xanthurenic Acid and Zinc in Diabetes / Ikeda, Sayoko / Kotake, Yahito -- Studies of the Clinical Importance and Molecular Defect of Hereditary Vitamin B6 Dependent Xanthurenic Aciduria / Knapp, Alwin / Grimm, Ulrich -- Tryptophan - Nicotinic Acid Pathway in Cardiovascular Diseases / Rudzite, Vera / Sileniece, Gunta / Jirgensons, Jánis -- The Dependence of Stress Induced Increases in Functional 5HT Activity on Increased Tryptophan Availability: Evidence that in vivo Electrochemistry Monitors 5-Hydroxyindole Release / Joseph, Michael H. / Kennett, Guy A. -- Increased Availability of Tryptophan to the Brain in Stress is not Mediated via Changes in Competing Amino Acids / Joseph, M. H. / Johnson, J. A. / Kennett, G. A. -- Free and Bound Plasma Tryptophan Levels in Psychiatric Disorders / Agarwal, D. P. / Ziemsen, B. / Goedde, H. W. / Philippu, G. / Milech, U. / Schrappe, O. -- Cerebrospinal Fluid 5HIAA and Tryptophan in Depression and Suicide / Banki, Csaba M. / Aratô, Mihâly / Papp, Zsuzsa / Kurcz, Mihâly -- The Influence of L5-Hydroxytryptophan (L5-HTP) on Clinical and Biochemical Parameters in Depressive Patients / Raba, M. / Riederer, P. / Danielczyk, W. / Seemann, D. -- Plasma Tryptophan Levels and 5-Hydroxytryptamine Synthesis in the Brain and the Spinal Cord in "Arthritic" Rats / Weil-Fugazza, Jeanne / Godefroy, Françoise / Bineau-Thurotte, Magali / Besson, Jean-Marie -- Effects of Antirheumatic Drugs and Tricyclic Antidepressants on Total and Free Serum Tryptophan Levels in Arthritic Rats / Godefroy, Françoise / Weil-Fugazza, Jeanne / Besson, Jean-Marie / Butler, Stephen H. -- Tryptophan, Serotonin and 5-Hydroxyindoleacetic Acid Levels in Human CSF in Relation to Pain / Costa, Carlo / Ceccherelli, Francesco / Bettero, Antonio / Marin, Gino / Mancusi, Ludovico / Allegri, Graziella -- Dynamics of Plasma Tryptophan Following Antimigraine Drugs / Salmon, Silvia / Del Re, Paola / Caleri, Daniela / Fanciullacci, Marcello / Sicuteri, Federigo -- Comparison of Morphine and Meptazinol Effects on Rat Tryptophan Disposition and Metabolism / Evans, Myrddin / Badawy, Abdulla A. -B. / Dacey, Anthony -- Decreased Concentrations of Tryptophan and Serotonin in the Brain of Developing Hyperphenylalaninemic Rats - A Contribution to the Understanding of the Metabolic Effects in Phenylketonuria / Huether, G. / Schott, K. / Neuhoff, V. -- Cofactor Dependency of Serotonin and Catecholamine Biosynthesis in Patients with Atypical Phenylketonuria and Endogenous Depression / Niederwieser, A. / Curtius, H. -Ch. / Levine, R. A. / Lovenberg, W. / Woggon, B. / Angst, J. / Müldner, H. / Leupold, D. -- Tryptophan, 5-Hydroxytryptophan and Dopa Metabolism in the Rat with Experimental Phenylketonuria / Byrd, D. J. / Arslan, M. / Meuter, H. / Bodammer, G. / Hunneman, D. -- The Role of Tryptophan Oxidation in Ocular Tissue Damage / Zigman, S. -- Tryptophan and Kynurenine in Senile Cataract / Allegri, Graziella / Angi, Mario R. / Costa, Carlo / Bettero, Antonio -- Urinary 5-Hydroxyindoleacetic Acid and Serum Phénobarbital of Children Suffering from Epilepsy / Milovanovic, Dragoslav / Stankovic, Branka / Milovanovic, Ljiljana / Koricanac, Zagorka / Trpkovic, Dragan -- Anticonvulsant Drugs Produce Different Effects on Plasma Tryptophan Concentrations in Epileptic Patients / Pratt, J. / Jenner, P. / Reynolds, E. H. / Shorvon, S. D. -- The Role of Metabolism in 3-Methylindole-Induced Acute Lung Injury / Carlson, J. R. / Nocerini, M. R. / Breeze, R. G. -- Beta-Carboline Levels in Blood of Smokers and Non-Smokers / Baumann, P. / Koeb, L. / Rivier, L. -- The Relationship between Tryptophan, Tryptophan Metabolites and Bladder Cancer / Wolf, H. -- Role of Indoleamine 2,3-Dioxygenase in the Defence Mechanism against Tumor Growth / Yoshida, R. / Takikawa, O. / Yasui, H. / Hayaishi, O. / Yasuhira, K. -- The Relationship between Plasma Kynurenine and Indoleamine 2,3-Dioxygenase Activity in the Extrahepatic Tissues / Takikawa, O. / Yoshida, R. / Yasui, H. / Hayaishi, O. -- L-Tryptophan Metabolism along the Kynurenine Pathway in Human Malignant Melanoma / Costa, C. / Lise, M. / Nitti, D. / De Antoni, A. / Zogno, A. / Cardin dè Stefani, E. / Allegri, G. -- NUTRITIONAL ASPECTS -- Content and Stability of Tryptophan in Foods / Nielsen, H. K. / Hurrell, R. F. -- Increased Aromatic Amine (Kynurenine) in Dried Fish Meat under Sunlight / Takahashi, Hitoshi -- Tryptophan Requirement of Farm Animals / Steinhart, Hans -- Pattern of Radioactivity from Endogenous 3H-Tryptophan Excreted in the Urine of Fasted or Rats Fed Diets Containing Different Levels of Casein / Finot, P. -A. / Magnenat, E. -- Protein/Carbohydrate Selection in Rats Following Administration of Tryptophan, Glucose or a Mixture of Amino Acids / Arimanana, L. / Ashley, D. / Furniss, D. / Leathwood, P. -- Influence of Tryptophan on Gastric Mucosal Protein Synthesis / Majumdar, A. P. N. -- Tryptophan and Intestinal Secretion / Cooke, Helen J. -- Tryptophan Metabolism in Undernourished Developing Rat Brain / Kalyanasundaram, S. / Ramanamurthy, P. S. V. -- Effect of Tryptophan on Protein Utilization and Energy Intake of Pigs / Menke, Karl-Heinz / Gruber, Friedrich -- A High Carbohydrate, Protein-Free Meal, either at Breakfast or in the Evening Does not Alter Plasma Tryptophan to Large Neutral Amino Acid Ratios in Healthy Men / Ashley, D. V. / Leathwood, P. D. -- Effects of Large Neutral Amino Acids on Tryptophan Transport into the Brain during Development / Ashley, D. V. / Fleury, M. / Hardwick, S. / Leathwood, P. D. / Moennoz, D. -- Contribution of Exegenous N15 -Tryptophan to Plasma and Red Blood Cell Tryptophan and Kynurenine in Healthy Humans / Ashley, D. V. / Finot, P. A. / Liardon, R. -- Carbohydrate Meal Increases Brain 5-Hydroxytryptamine Synthesis in the Adult Rat only after Prolonged Fasting / Ashley, D. V. / Leathwood, P. D. / Moennoz, D. -- Exogenous Tryptophan: A Study of its Effects on the Levels of Aromatic Amine(s) in Cerebral and Hepatic Tissues in Mice / Ghosh, D. / Affiah, I. U. / Guilford, J. / Henderson, L. L. -- Influence of Excess Leucine Intake on the Conversion of Tryptophan to NAD in Rats Fed Low Protein Diet / Suzuki, T. / Yuyama, S. / Sasaki, A. / Yatnada, M. / Kumagai, R. -- The Pellagragenic Action of a Dietary Excess of Leucine: Effects of a High-Leucine Diet on Tryptophan Metabolism / Bender, D. A. / Magboul, B. I. -- Effect of Cadmium on some Key Enzymes of Tryptophan - NAD Pathway in Rats in vivo / Yuyama, Shunsuke / Sasaki, Atuko / Suzuki, Takeshi -- The Influence of Increased Availability of Tryptophan on the Formation of Tryptamine and Serotonin during Early Ontogenesis / Huether, Gerald -- TRYPTOPHAN METABOLISM IN MAMMALS -- Tryptophan Metabolism and its Control in Mammalian Liver / Pogson, Ch. I. / Munoz-Clares, R. A. / Cook, J. S. / Smith, S. A. -- Tryptophan Metabolism by the Isolated, Perfused Liver and Kidney of Rat (Quantification of the Metabolism by the Compartmental Analysis) / Otsuka, H. / Nomura, S. / Takeuchi, F. / Yokomine, R. / Fujimoto, H. / Ugata, M. / Shibata, Y. -- Effects of Oestrogens on the Metabolism of Tryptophan Implications for the Interpretation of the Tryptophan Load Test for Vitamin B6 Nutritional Status / Bender, David A. -- The Functions and Regulation of Tryptophan Pyrrolase / Badawy, A. A. -B. -- Kynurenine Aminotransferase Activity in Human and other Mammalian Tissues / Kido, R. -- Intracellular Localization and Characterization of 3-Hydroxykynureninase in Human Liver / Inada, J. / Kimura, M. / Okuno, E. / Kido, R. -- Time-Course of 5-HTP Metabolism in Rabbits: Relevance of Transaminating Pathway / Politi, V. / De Luca, G. / Di Stazio, G. / Palamara, G. / Materazzi, M. -- Tryptophan Aminotransferase Activity in Rat Liver / Stanley, J. / Nicholas, A. / Thompson, I. / Pogson, Ch. -- The Oxygenation of Tryptophan and Indoles with Superoxide Ion and Dioxygen in the Presence of Copper and Ruthenium Catalysts / Balogh-Hergovich, É. / Speier, G. -- Serotonin- and Melatonin-Dependent Light Emission Induced by Xanthine Oxidase / Uemura, T. / Kadota, K. -- The in vivo Effect of Sodium Fluoride on the Key Enzymes of Tryptophan Metabolism / Geeraerts, F. / Schimpfessel, L. / Crokaert, R. -- Roles of Active Oxygen and Superoxide Dismutase in Anthranilatnide Hydroxylation and its Derived Phenoxazinone-Like Pigment Formation by Rat Liver Microsomal Monooxygenase System / Ohta, V. / Shinohara, R. / Naito, J. / Ishiguro, I. -- Protective Effect of Tryptophan upon the Influence of N-Methylformamide on the Development, the NAD Synthesis, and the Activity of the Adenosine Diphosphate Ribosyl Transferase of Rat Embryos / Kröger, H. / Grätz, R. / Grahn, H. -- Induction of Tyrosine Aminotransferase by Tryptophan in Rat Liver / Kröger, H. / Grätz, R. -- TRYPTOPHAN METABOLISM IN INSECTS -- Tryptophan Metabolism in Drosophila / Sullivan, D. T. -- Roles of Active Oxygen and Catalase in the Formation of Phenoxazinone Pigments Catalysed by Manganese Ion / Ogawa, H. / Nagarnura, Y. / Ishiguro, I. -- Ommochrome-Potassium Urate Complex as Pigment of Red Faeces of Locusta migratoria (Insecta, Orthoptera, Acrididae) / Bouthier, A. E. -- Changes in Fluorescence and Size of the Cytoplasmic Granules in the Malpighian Tubules of Drosophila melanogaster Linked with Tryptophan Metabolism / Yagi, S. -- Hormonal Control of Pigmentation in Manduca sexta / Riddiford, L. M. / Hiruma, K. -- Tryptophan Metabolism and Morphological Color Change in Insects / Bückmann, D. -- The Structure of Papiliochrome II, the Yellow Wing Pigment of the Papilionid Butterflies / Rembold, H. / Umebachi, Y. -- Some Chemical Properties of Papiliochrome R / Umebachi, Yoshishige -- TRYPTOPHAN METABOLISM IN PLANTS AND MICROORGANISMS -- Metabolism of Tryptophan in Pseudomonas aureofaciens / Pée, K.-H. van / Lingens, Franz -- Does Tryptophan Side Chain Oxidase from Pseudomonas ATCC 29574 Contain a Quinoprotein? / Graaff, W. van der / Duine, J. A. / Frank, J. / Jzn / Jongejan, J. A. -- Tryptophan Side Chain Oxidase (TSO) - Structure and Reaction Mechanism / Takai, K. / Inoue, S. / Zavala, F. / Müller, R. / Hamasaki, T. / Sasai, Y. -- Characterization of three Tryptophan Aminotransferases from Candida maltosa / Bode, R. / Birnbaum, D. -- Anthranilate Hydroxylase and the Short-Cut-Pathway for the Biosynthesis of Nicotinamide Nucleotides in Aspergillus niger / Schott, H.-H. / Zinke, K. / Langenbach-Schmidt, D. -- Biosynthesis of Tryptophan Derived Alkaloids in Higher Plants: Enzymati Formation of the Sarpagine-Ajmaline Group / Stöckigt, J. -- Acridone Alkaloid Biosynthesis in Tissue Cultures of Ruta graveolens / Gröger, Detlef / Baumert, Alfred -- Isolation and Biological Activities of Diterpene Anthraniloyl and 3-Hydroxyanthraniloyl Peptide Esters from Euphorbia mi Iii / Marston, A. / Hecker, E. -- New Biological Significance of Indole-Containing Compounds as Initiators or Tumor Promoters in Chemical Carcinogenesis / Fujiki, H. / Suganuma, M. / Tahira, T. / Esumi, M. / Nagao, M. / Wakabayashi, K. / Sugimura, T. / Takayama, S. -- Biosynthesis of Serotonin and Auxin in Seeds of Juglans regia / Große, Wolfgang -- Blepharismone: a Conjugation-Inducing Tryptophan Derivative in the Ciliate Blepharisma / Miyake, Akio -- Biological Activity of Blepharismone Derivatives - An Approach Towards Biogenesis of the Hormone / Jaenicke, Lothar -- TRYPTOPHAN IN PROTEINS AND PEPTIDES -- Advances in the Chemical Modification of Tryptophan in Peptides and Proteins / Fontana, A. -- Peptide Bond Cleavage at Tryptophan with Cyanogen Bromide - Mechanism of the Reaction / Fontana, A. / Grandi, C. / Dalzoppo, D. / Zambonin, M. -- Tryptophan, a Pitfall for the Peptide Chemist / Moroder, L. / Wünsch, E. -- Photochemical arid Radiochemical Reactions of Tryptophan: Modification of a Single-Strand Binding Protein from Bacteriophage T4 / Toulmé, Jean-Jacques -- X-Ray Structure Analyses of Tryptophan Derivatives as Models for Stereochemical Aspects of the Toxic Peptides from Amanita Mushrooms / Gieren, A. / Lamm, V. / Sturm, M. -- AUTHOR INDEX -- SUBJECT INDEX -- ABBREVATIONS -- Backmatter