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Anglický jazyk
Role of Inteleuchin-6 in breast cancer stem-like cells
Autor: Pasquale Sansone
Inflammation triggers pathological warnings in the human body including infection, autoimmune disease, metabolic syndrome and cancer. In this book the authors determine the molecular effect of the pro-inflammatory cytokine IL-6 in breast cancer. The authors... Viac o knihe
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O knihe
Inflammation triggers pathological warnings in the human body including infection, autoimmune disease, metabolic syndrome and cancer. In this book the authors determine the molecular effect of the pro-inflammatory cytokine IL-6 in breast cancer. The authors describe several mechanisms by which IL-6 exposure can foster tumor progression via the expansion of a specific population of cancer cells, called cancer stem cells (CSCs). These cells represent a small fraction of each tumor and dictate tumor progression toward a pro-metastatic phenotype. The authors unravel a unique mechanism by means IL-6 mediated the conversion of non-stem cells into CSCs capable of surviving in tumor-stoma niches and hypoxic niches. Inflammation, hypoxia, CSCs and breast cancer share the up-regulation of IL-6 as a common mediator of malignancy.
- Vydavateľstvo: Scholars' Press
- Rok vydania: 2017
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783330651500
