• Anglický jazyk

Some novel 1, 4-thiazepine derivatives

Autor: S. Sarveswari

The 1, 4-thiazepine fused derivatives were synthesized by L-proline catalyzed one-pot mechanistic pathway. Though L-proline is being amphoteric molecule with both amine end carboxylic acid end, it worked as an enamine base for the catalysis. We aim to synthesize... Viac o knihe

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O knihe

The 1, 4-thiazepine fused derivatives were synthesized by L-proline catalyzed one-pot mechanistic pathway. Though L-proline is being amphoteric molecule with both amine end carboxylic acid end, it worked as an enamine base for the catalysis. We aim to synthesize organic molecules with anti-cancer activity. This protocol provides a synthetic route for the efficient synthesis of 1, 4 -thiazepines. All the synthesized molecules were screened for the cytotoxicity studies. We have screened the synthesized 1, 4-thiazepines against to six cell lines, namely ¿Pancreas (PANC1), Renal (ACHN), Colon (HCT116), Non-small cell lung (H460), Lung (CALUl) and Normal breast epithelium (MCF10A)¿ with two concentration 1¿M and 10¿M concentration levels.

  • Vydavateľstvo: LAP LAMBERT Academic Publishing
  • Rok vydania: 2023
  • Formát: Paperback
  • Rozmer: 220 x 150 mm
  • Jazyk: Anglický jazyk
  • ISBN: 9786205633953

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