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Anglický jazyk
Studies on divergent CRP-dependent promoters
Autor: Mohamed Elrobh
Bacterial genomes contain genes that are packed closely together. For many genes, promoter regions overlap, and regulatory segments that carry divergent promoters are common. In this study, I have focussed on promoters that are regulated by the cyclic... Viac o knihe
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O knihe
Bacterial genomes contain genes that are packed closely together. For many genes, promoter regions overlap, and regulatory segments that carry divergent promoters are common. In this study, I have focussed on promoters that are regulated by the cyclic AMP receptor protein (CRP) of Escherichia coli. CRP is a global regulator that directs the activity of more than 100 genes, some of which are oriented back-to-back, i.e., in a divergent fashion. CRP is known to activate transcription initiation through direct protein-protein contact with RNA polymerase and CRP-dependent promoters are classified into two classes, Class I and Class II, according to the location of the CRP-binding site. I have investigated whether a single bound CRP, either at a Class I or a Class II location, can activate divergent transcription.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2010
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783838351971
