SYNTHESIS AND MICROBIAL SCREENING OF SOME GLUCOPYRANOSIDE DERIVATIVES

Anglický jazyk

SYNTHESIS AND MICROBIAL SCREENING OF SOME GLUCOPYRANOSIDE DERIVATIVES

Vydavateľstvo: Scholars' Press
Rok vydania: 2020
Formát: Paperback
Rozmer: 220 x 150 mm
Jazyk: Anglický jazyk
ISBN: 9786138938125

Na objednávku, dodanie 2-4 týždne

62.82 €

bežná cena: 69.80 €

O knihe

Methyl a-D-glucopyranoside was easily prepared by the treatment of D-glucose with anhydrous methyl alcohol in the presence of hydrogen chloride at freezing temperature. Then N-acetylsulfanilylation of methyl a-D-glucopyranoside has been carried out by the direct method and afforded the 6-O-N-acetylsulfanilyl derivative in an excellent yield. In order to obtain newer products, the 6-O-N-acetylsulfanilyl derivative was further transformed into a series of 2,3,4-tri-O-acyl derivatives containing a wide variety of functionalities in a single molecular framework. The chemical structures of the newly synthesized compounds were elucidated by FTIR, Proton nuclear magnetic resonance spectroscopy, elemental and physicochemical properties analysis. All the newly synthesized D-glucose derivatives were tested for their in vitro antibacterial activity against some human pathogenic bacterial strains. The study revealed that a good number of compounds exhibited promising antibacterial activities. It is expected that the acylated derivatives of D-glucose may be considered as a potential source for developing new and better antibacterial agents against a number of pathogenic organisms.