University of Konstanz, West Germany, April 14-18, 1975

Frontmatter -- Preface -- Contents -- List of Contributors -- Significant Steps in the Discovery and Application of Pteridines / Albert, A. -- Specific Inhibition of Dihydrofolate Biosynthesis - A New Approach to Chemotherapy / Wood, H.C.S. -- Mammalian Dihydrofolate Reductase: Porcine Liver Enzyme / Poe, M. / Bennett, C.D. / Donoghue, D. / Hirshfield, J.M. / Williams, M.N. / Hoogsteen, K. -- Kinetic Studies of Escherichia Coli Dihydropteroate Synthetase / Ferone, R. / Webb, S.R. -- Dihydropteroate Synthase: Purification by Affinity Chromatography and Mechanism of Action / Suckling, C.J. / Sweeney, J.R. / Wood, H.C.S. -- The Properties of Gamma Glutamyl Hydrolase (Conjugase) from Bovine Liver / Rowe, P.B. / Silink, M. / Reddel, R. -- The Purification of Riboflavin Synthetase by Affinity Chromatography Using 7-Oxolumazines / Wrigglesworth, R. / Ginger, C.D. / Kulick, R.J. / Wood, H.C.S. -- Interaction of Riboflavin Synthetase with Analogues of 6,7-Dimethyl-8-Ribityllumazine / Plaut, G.W.E. / Beach, R.L. -- Structure-Activity Relationship Among Pteridine Derivatives and Related Quinazolines as Inhibitors of Dihydrofolate Reductases / McCormack, John J. -- Spectral Studies of Thymidylate Synthetase / Kisliuk, R.L. / Sharma, R.K. / Leary, R.P. / Beaudette, N. -- Four Folate Metabolizing Enzymes of Mouse Embryo Fibroblasts and L-Cells as Tested During the Culture Cycle / Grzelakowska-Sztabert, B. / Chmurzyriska, W. / Landman, M. -- The Activity of the Cobalamine-dependent Methionine- Synthetase (5-Methyl-5, 6, 7, 8-Tetrahydrofolic Acid: Homocysteine Methyltransferase) in Rapidly Growing Human Cells and the Effect of Some Folic Acid Derivatives and Analogues / Sauer, H. / Wilmanns, W. -- The Role of Folate Binding Proteins in Folate Metabolism / Waxman, S. -- Transport of Folate Compounds into Mammalian and Bacterial Cells / Huennekens, F.M. / Henderson, G.B. -- Transport of Folate Compounds through the Membrane of Human Lymphoblastoid Cells / Niethammer, D. / Jackson, R.C. -- The Characterization of High Molecular Weight Complexes of Folic Acid in Mammalian Tissues / Zamierowski, M. / Wagner, C. -- The Enzymic Synthesis of Pterins in Escherichia Coli / Brown, G.M. / Yim, J. / Suzuki, Y. / Heine, M.C. / Foor, F. -- Biosynthesis of Pterins in Mammalian Systems / Fukushima, K. / Eto, I. / Mayumi, T. / Richter, W. / Goodson, S. / Shiota, T. -- The Synthesis of Pterins Catalyzed by Enzymes from Drosophila melanogaster / Brown, G.M. / Fan, C.L. -- Biosynthesis of Biopterin in the Intact Rat and in Mouse Neuroblastoma Cells / Buff, K. / Dairman, W. -- Studies on the Biosynthesis of Riboflavin / Bacher, A. / Mailänder, B. / Baur, R. / Eggers, U. / Harders, H. / Schnepple, H. -- Studies on the Mechanism of Phenylalanine Hydroxylase: Detection of an Intermediate / Kaufman, S. -- Effect of Pteridine Cofactor Structure on the Regulation of Phenylalanine Hydroxylase Activity / Ayling, J.E. / Helfand, G.D. -- Interrelationships between C-1 Metabolism and Photosynthesis in Euglena Gracilis / Cossins, E.A. / Lor, K.L. -- Folate Derivatives and Patterns of C-1 Metabolism in Neurospora Crassa, Wild Type, Ser-1 and Formate Mutants / Combepine, G. / Cossins, E.A. / Chan, P.Y. -- The Biosynthesis of Folic Acid and Pteridine Cofactor (s) and its Regulation / Iwai, K. / Kobashi, M. -- Reduced Pterins as Possible Mediators in Cellular Electron Transfer / Rembold, H. -- The Handling and Metabolism of Folates in the Rat and Man, with Especial Relationship to Disease / Blair, J.A. -- Red Blood Cell Polyglutamyl Folates in Vitamin B12 Deficiency / Perry, J. / Chanarin, I. / Lumb, M. -- Novel Urinary Metabolites of Folic Acid in the Rat / Barford, P.A. / Blair, J.A. -- "Prune"/"Killer-of-Prune": A Complementary Lethal System in Drosophila Melanogaster Affecting Pteridine Metabolism / Hackstein, J.H.P. -- Kynurenine as Trigger in Pterorhodin Synthesis in Ephestia Kuhniella Z. / Müller, K. -- Growth Stimulation by 6-Phenacylisoxanthopterin and Related Compounds / Iwanama, Y. -- The Possible Role in Gene Regulation of an Isoxanthopterinbinding Protein from Oncopeltus Embryos / Forrest, H.S. / Smith, J.H. -- Poly-¿-Glutamyl Chain Lengths in some Natural Folates and Contributions of Folic Acid Synthesized by Intestinal Microflora to Rat Nutrition / Baugh, Ch.M. / Braverman, E. / Nair, M.G. -- Tissue-Specific Synthesis of Methotrexate Polyglutamates in the Rat / Whitehead, V.M. / Perrault, M.M. / Stelcner, S. -- A Convenient Synthesis of Methotrexate and Related Compounds / Montgomery, J.A. / Rose, J.D. / Temple, C. / Piper, J.R. -- Methods for the Synthesis of Folic Acid Analogs, Substituted Folic Acid Analogs, Folic Acid and Folic Acid Conjugates / Sengupta, P.K. / Khalifa, E. / Bieri, J.H. / Viscontini, M. -- New Folate Analogs: Alterations in the C9-N10 Region / Nair, M.G. / Baugh, Charles M. -- The Synthesis and Study of 10-Thia-10-Deaza-Analogs of Pteroic Acid, Folic Acid, and of Related Compounds: The Problem of Racemization in the Cyclization of Substituted 2-Amino-3-Cyanopyrazines / Mautner, H.G. / Kim, Y.H. / Gaumont, Y. / Kisliuk, R.L. -- Synthesis and Properties of 5-Methyldihydrofolate / Deits, T.L. / Russel, A. / Fujii, K. / Whiteley, J.M. -- A Coloured Oxidation Product from Tetrahydrofolate / Rimkus, B. / Jaenicke, L. / Rüdiger, H. -- Pteridine Synthesis / Taylor, E.C. -- The 7-Azapteridines / Brown, D.J. / Lynn, R.K. -- Enzymatic Oxidation of Pteridin-4-ones and Related Compounds / Bergmann, F. / Levene, L. / Tamir, I. -- Synthesis and Structure of Dihydro- and Tetrahydroderivatives of Pterin 6,7-Dicarboxylic Acid / Mengel, R. / Pfleiderer, W. -- Direct Conversion of 4-Hydroxypteridines to their 4-Amino Analogs / Gapski, G.R. / Whiteley, J.M. -- High Pressure Liquid Chromatography of Substituted Pteridines and Tetrahydropteridines / Bailey, S.W. / Ayling, J.E. -- Electrochemistry of Pteridines / Lund, H. -- Pteridone Mediators in the Electrolysis of Biological Macromolecules / Kwee, S. -- Electrochemistry of 6,7-Dioxo-Pteridines / Gottlieb, R. / Pfleiderer, W. -- Protonation and Covalent Hydration of Nitrogen Heterocycles - A Carbon-13 NMR Study [1] / Ewers, U. / Gronenborn, A. / Günther, H. / Jaenicke, L. -- Reindarstellung und NMR-Spektroskopische Untersuchung von 5, 6, 7, 8-Tetrahydrofolsäure / Frick, W. -- Sterische Wechselwirkungen in Substituierten Tetrahydropterinen / Weber, R. -- Kinetisch-Mechanistische Untersuchungen an 5-Formyl-6, 7-Dimethyl-5, 6, 7, 8-Tetrahydropterin, 10-Formyl-Folsäure, 5,10-Methenyl-5, 6, 7, 8-Tetrahydrofolsäure und 5-Methyl-10-Formyl-5, 6, 7, 8- Tetrahydrofolsäure / Bieri, J.H. -- CNDO-Rechnungen an Pterin, 6, 7-Dimethyl-7, 8- Dihydropterin und 5-Formyl-6, 7-Dimethyl-5, 6, 7, 8- Tetrahydropterin [1] / Bieri, J.H. -- H-D Exchange in Pteridin-4-ones / Bergmann, F. / Tamir, I. / Levene, L. / Rahat, M. -- Oxidation-Reduction Properties of Pterins / Scrimgeour, K.G. -- Autoxidative Conversions of Tetrahydropteridines and some Related Ringsystems / Mager, H.I.X. -- Autoxidation of Tetrahydropterins / Pearson, A.J. / Blair, J.A. -- Synthesis of Thiolumazine Nucleosides / Southon, I. / Pfleiderer, W. -- Pteridine Nucleotides, Synthesis and Enzymic Studies / Rokos, H. / Harzer, G. -- Biology of Pigmentation in Pieridae Butterflies / Descimon, H. -- The Pterins of the Pieridae and their Biosynthesis: Metabolism of D-Erythro-Neopterin and its 7, 8- Dihydro Derivative in Colias Croceus / Descimon, H. -- Occurrence and Distribution of Known Pterins in Some Species of Diptera / Cenoni, E. / Contini, C. / Laudani, U. -- Pteridines in the Mammalian Retina and Light Effects / Cremer-Bartels, G. -- Les Pterines des Planctons Marins: Identification de plusieurs Dérivés chez les Algues Unicellulaires. Sur la Distribution des Pterines chez la Crustacés Copepodes / Momzikoff, A. -- Russupteridine / Eugster, C.H. / Iten, P.X. -- Aurodrosopterins in Eye Colour Mutants of Drosophila Melanogaster / Schwinck, I. -- New Results about Drosopterins / Rokos, K. / Pfleiderer, W. -- Synthesis and Absolute Configuration of Sepiapterin / Pfleiderer, W. -- Backmatter